In shotgun sequencing many copies of the entire genome are "blown up" into millions of small fragments. Each small fragment is sequenced. Powerful computers then assemble the individual fragments into the original configuration. Repeat sequences pose a problem for this approach because their sizes can be much larger than the small fragments.
Used with permission from the Howard Hughes Medical Institute, Copyright (2003). All rights reserved. www.BioInteractive.org.
This resource is part of the Post 16 genetics and genomics collection of resources.