Mutation, evolution and disease

A collection of post 16 resources about mutation, evolution and disease.  These resources are part of the post 16 genetics and genomics collection.

Resources

GENIE jumping genes

The aim of this activity is for students to use tiddlywinks to represent sections of jumping genes, which they then flick onto a poster which is representative of a section of the human genome. Where their "gene" lands either will or will not disrupt the gene and may then cause disease. An accompanying PowerPoint...

BRAF: from gene to cancer therapy

This film tells the story of how DNA sequencing was used to identify the gene BRAF. Clinical researcher Ultan McDermott tells the story of how scientists at the Wellcome Trust Sanger Institute discovered a specific mutation in the BRAF gene, which is found in around half of malignant melanoma cases. He...

Damage to DNA leads to mutation

Reactive molecules, such as free radicals, and solar ultraviolet radiation can lead to mutations in DNA. Most mutations are corrected, but in rare cases mutations can accumulate and cause diseases such as cancer.

Used with permission from the Howard Hughes Medical Institute, Copyright (2003).  All rights...

Mismatch repair

This animation illustrates how mistakes made during DNA replication are repaired. 

During DNA replication mistakes can occur as DNA polymerase copies the two strands. The wrong nucleotide can be incorporated into one of the strands causing a mismatch. Normally there should be an "A" opposite a "T" and "G"...

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