In the early days of DNA manipulation, DNA fragments were laboriously separated by gravity. In the 1970s, the powerful tool of DNA gel electrophoresis was developed. This process uses electricity to separate DNA fragments by size as they migrate through a gel matrix. Gel electrophoresis can be used to separate DNA fragments. Electrophoresis uses electric current ot separate different sized molecules in a porous, sponge-like matrix. Smaller molecules move more easily through the gel pores than larger molecules.
This resource is part of the Post 16 genetics and genomics collection of resources.